#lang racket ;;; dds/networks ;;; This module provides some quick definitions for and analysing ;;; network models. A network is a set of variables which are updated ;;; according to their corresponding update functions. The variables ;;; to be updated at each step are given by the mode. ;;; ;;; This model can generalise Boolean networks, TBANs, multivalued ;;; networks, etc. (require "utils.rkt" "generic.rkt" graph) (provide ;; Structures (struct-out dynamics) ;; Functions (contract-out [update (-> network? state? (set/c variable? #:kind 'dont-care) state?)] [make-state (-> (listof (cons/c symbol? any/c)) state?)] [make-state-booleanize (-> (listof (cons/c symbol? (or/c 0 1))) state?)] [booleanize-state (-> state? state?)] [make-network-from-functions (-> (listof (cons/c symbol? update-function/c)) network?)] [update-function-form->update-function (-> update-function-form? update-function/c)] [network-form->network (-> network-form? network?)] [make-network-from-forms (-> (listof (cons/c symbol? update-function-form?)) network?)] [list-interactions (-> network-form? variable? (listof variable?))] [build-interaction-graph (-> network-form? graph?)] [build-all-states (-> domain-mapping/c (listof state?))] [make-same-domains (-> (listof variable?) generic-set? domain-mapping/c)] [make-boolean-domains (-> (listof variable?) (hash/c variable? (list/c #f #t)))] [build-all-boolean-states (-> (listof variable?) (listof state?))] [get-interaction-sign (-> network-form? domain-mapping/c variable? variable? (or/c '+ '- '0))] [build-signed-interaction-graph (-> network-form? domain-mapping/c graph?)] [build-boolean-signed-interaction-graph (-> network-form? graph?)] [make-asyn (-> (listof variable?) mode?)] [make-syn (-> (listof variable?) mode?)] [make-dynamics-from-func (-> network? (-> (listof variable?) mode?) dynamics?)] [make-asyn-dynamics (-> network? dynamics?)] [make-syn-dynamics (-> network? dynamics?)] [read-org-network-make-asyn (-> string? dynamics?)] [read-org-network-make-syn (-> string? dynamics?)] [dds-step-one (-> dynamics? state? (set/c state?))] [dds-step-one-annotated (-> dynamics? state? (set/c (cons/c modality? state?)))] [dds-step (-> dynamics? (set/c state? #:kind 'dont-care) (set/c state?))] [dds-build-state-graph (-> dynamics? (set/c state? #:kind 'dont-care) graph?)] [dds-build-n-step-state-graph (-> dynamics? (set/c state? #:kind 'dont-care) number? graph?)] [dds-build-state-graph-annotated (-> dynamics? (set/c state? #:kind 'dont-care) graph?)] [dds-build-n-step-state-graph-annotated (-> dynamics? (set/c state? #:kind 'dont-care) number? graph?)] [pretty-print-state (-> state? string?)] [any->boolean (-> any/c boolean?)] [pretty-print-boolean-state (-> state? string?)] [pretty-print-state-graph-with (-> graph? (-> state? string?) graph?)] [pretty-print-state-graph (-> graph? graph?)] [pretty-print-boolean-state-graph (-> graph? graph?)] [build-full-boolean-state-graph (-> dynamics? graph?)] [build-full-boolean-state-graph-annotated (-> dynamics? graph?)] [tabulate/domain-list (-> procedure? (listof generic-set?) (listof list?))] [tabulate (->* (procedure?) () #:rest (listof generic-set?) (listof list?))] [tabulate/boolean (-> procedure-fixed-arity? (listof (listof boolean?)))] [table->function (-> (listof (*list/c any/c any/c)) procedure?)] [table->function/list (-> (listof (*list/c any/c any/c)) procedure?)] [boolean-power-n (-> number? (listof (listof boolean?)))] [boolean-power-n/stream (-> number? (stream/c (listof boolean?)))] [enumerate-boolean-tables (-> number? (stream/c (listof (*list/c any/c any/c))))] [enumerate-boolean-functions (-> number? (stream/c procedure?))] [enumerate-boolean-functions/list (-> number? (stream/c procedure?))]) ;; Predicates (contract-out [variable? (-> any/c boolean?)] [state? (-> any/c boolean?)] [update-function-form? (-> any/c boolean?)] [network-form? (-> any/c boolean?)] [modality? (-> any/c boolean?)] [mode? (-> any/c boolean?)]) ;; Contracts (contract-out [state/c contract?] [network/c contract?] [update-function/c contract?] [domain-mapping/c contract?]) ;; Syntax st stb nn ppsg ppsgb unorg-syn unorg-asyn) ;;; ================= ;;; Basic definitions ;;; ================= (define variable? symbol?) ;;; A state of a network is a mapping from the variables of the ;;; network to their values. (define state? variable-mapping?) (define state/c (flat-named-contract 'state state?)) ;;; An update function is a function computing a value from the given ;;; state. (define update-function/c (-> state? any/c)) ;;; A network is a mapping from its variables to its update functions. (define network? variable-mapping?) (define network/c (flat-named-contract 'network network?)) ;;; Given a state s updates all the variables from xs. This ;;; corresponds to a parallel mode. (define (update network s xs) (for/fold ([new-s s]) ([x xs]) (let ([f (hash-ref network x)]) (hash-set new-s x (f s))))) ;;; A version of make-immutable-hash restricted to creating network ;;; states (see contract). (define (make-state mappings) (make-immutable-hash mappings)) ;;; A shortcut for make-state. (define-syntax-rule (st mappings) (make-state mappings)) ;;; Makes a new Boolean states from a state with numerical values 0 ;;; and 1. (define (make-state-booleanize mappings) (make-state (for/list ([mp mappings]) (match mp [(cons var 0) (cons var #f)] [(cons var 1) (cons var #t)])))) ;;; Booleanizes a given state: replaces 0 with #f and 1 with #t. (define (booleanize-state s) (for/hash ([(x val) s]) (match val [0 (values x #f)] [1 (values x #t)]))) ;;; A shortcut for make-state-booleanize. (define-syntax-rule (stb s) (booleanize-state s)) ;;; A version of make-immutable-hash restricted to creating networks. (define (make-network-from-functions funcs) (make-immutable-hash funcs)) ;;; ================================= ;;; Syntactic description of networks ;;; ================================= ;;; An update function form is any form which can appear as a body of ;;; a function and which can be evaluated with eval. For example, ;;; '(and x y (not z)) or '(+ 1 a (- b 10)). (define update-function-form? any/c) ;;; A Boolean network form is a mapping from its variables to the ;;; forms of their update functions. (define network-form? variable-mapping?) ;;; Build an update function from an update function form. (define (update-function-form->update-function form) (λ (s) (eval-with s form))) ;;; Build a network from a network form. (define (network-form->network bnf) (for/hash ([(x form) bnf]) (values x (update-function-form->update-function form)))) ;;; Build a network from a list of pairs of forms of update functions. (define (make-network-from-forms forms) (network-form->network (make-immutable-hash forms))) ;;; A shortcut for network-form->network. (define-syntax-rule (nn forms) (network-form->network forms)) ;;; ============================ ;;; Inferring interaction graphs ;;; ============================ ;;; I allow any syntactic forms in definitions of Boolean functions. ;;; I can still find out which Boolean variables appear in those ;;; syntactic form, but I have no reliable syntactic means of finding ;;; out what kind of action do they have (inhibition or activation) ;;; since I cannot do Boolean minimisation (e.g., I cannot rely on not ;;; appearing before a variable, since (not (not a)) is equivalent ;;; to a). On the other hand, going through all Boolean states is ;;; quite resource-consuming and thus not always useful. ;;; ;;; In this section I provide inference of both unsigned and signed ;;; interaction graphs, but since the inference of signed interaction ;;; graphs is based on analysing the dynamics of the networks, it may ;;; be quite resource-consuming. ;;; Lists the variables of the network form appearing in the update ;;; function form for x. (define (list-interactions nf x) (set-intersect (extract-symbols (hash-ref nf x)) (hash-keys nf))) ;;; Builds the graph in which the vertices are the variables of a ;;; given network, and which contains an arrow from a to b whenever a ;;; appears in (list-interactions a). (define (build-interaction-graph n) (transpose (unweighted-graph/adj (for/list ([(var _) n]) (cons var (list-interactions n var)))))) ;;; A domain mapping is a hash set mapping variables to the lists of ;;; values in their domains. (define domain-mapping/c (hash/c variable? list?)) ;;; Given a hash-set mapping variables to generic sets of their ;;; possible values, constructs the list of all possible states. (define (build-all-states vars-domains) (let* ([var-dom-list (hash->list vars-domains)] [vars (map car var-dom-list)] [domains (map cdr var-dom-list)]) (for/list ([s (apply cartesian-product domains)]) (make-state (for/list ([var vars] [val s]) (cons var val)))))) ;;; Makes a hash set mapping all variables to a single domain. (define (make-same-domains vars domain) (for/hash ([var vars]) (values var domain))) ;;; Makes a hash set mapping all variables to the Boolean domain. (define (make-boolean-domains vars) (make-same-domains vars '(#f #t))) ;;; Builds all boolean states possible over a given set of variables. (define (build-all-boolean-states vars) (build-all-states (make-boolean-domains vars))) ;;; Given two interacting variables of a network form and the domains ;;; of the variables, returns '+ if the interaction is monotonously ;;; increasing, '- if it is monotonously decreasing, and '0 otherwise. ;;; ;;; This function does not check whether the two variables indeed ;;; interact. Its behaviour is undefined if the variables do not ;;; interact. ;;; ;;; /!\ This function iterates through almost all of the states of the ;;; network, so its performance decreases very quickly with network ;;; size. (define (get-interaction-sign network-form doms x y) (let* ([dom-x (hash-ref doms x)] [dom-y (hash-ref doms y)] [network (network-form->network network-form)] ;; Replace the domain of x by a dummy singleton. [doms-no-x (hash-set doms x '(#f))] ;; Build all the states, but as if x were not there: since I ;; replace its domain by a singleton, all states will contain ;; the same value for x. [states-no-x (build-all-states doms-no-x)] ;; Go through all states, then through all ordered pairs of ;; values of x, generate pairs of states (s1, s2) such that x ;; has a smaller value in s1, and check that updating y in s1 ;; yields a smaller value than updating y in s2. I rely on ;; the fact that the domains are ordered. [x-y-interactions (for*/list ([s states-no-x] [x1 dom-x] ; ordered pairs of values of x [x2 (cdr (member x1 dom-x))]) (let* ([s1 (hash-set s x x1)] ; s1(x) < s2(x) [s2 (hash-set s x x2)] [y1 ((hash-ref network y) s1)] [y2 ((hash-ref network y) s2)]) ;; y1 <= y2? (<= (index-of dom-y y1) (index-of dom-y y2))))]) (cond ;; If, in all interactions, y1 <= y2, then we have an ;; increasing/promoting interaction between x and y. [(andmap (λ (x) (eq? x #t)) x-y-interactions) '+] ;; If, in all interactions, y1 > y2, then we have an ;; decreasing/inhibiting interaction between x and y. [(andmap (λ (x) (eq? x #f)) x-y-interactions) '-] ;; Otherwise the interaction is neither increasing nor ;; decreasing. [else '0]))) ;;; Constructs a signed interaction graph of a given network form, ;;; given the ordered domains of its variables. The order on the ;;; domains determines the signs which will appear on the interaction ;;; graph. ;;; ;;; /!\ This function iterates through almost all states of the ;;; network for every arrow in the unsigned interaction graph, so its ;;; performance decreases very quickly with the size of the network. (define (build-signed-interaction-graph network-form doms) (let ([ig (build-interaction-graph network-form)]) (weighted-graph/directed (for/list ([e (in-edges ig)]) (match-let ([(list x y) e]) (list (match (get-interaction-sign network-form doms x y) ['+ 1] ['- -1] ['0 0]) x y)))))) ;;; Calls build-signed-interaction-graph with the Boolean domain for ;;; all variable. ;;; ;;; /!\ The same performance warning applies as for ;;; build-signed-interaction-graph. (define (build-boolean-signed-interaction-graph network-form) (build-signed-interaction-graph network-form (make-boolean-domains (hash-keys network-form)))) ;;; ==================== ;;; Dynamics of networks ;;; ==================== ;;; This section contains definitions for building and analysing the ;;; dynamics of networks. ;;; A modality is a set of variable. (define modality? (set/c variable?)) ;;; A mode is a set of modalities. (define mode? (set/c modality?)) ;;; A network dynamics is a network plus a mode. (struct dynamics (network mode) #:methods gen:dds [;; Annotates each result state with the modality which lead to it. (define/match (dds-step-one-annotated dyn s) [((dynamics network mode) s) (for/set ([m mode]) (cons m (update network s m)))])]) ;;; Given a list of variables, builds the asynchronous mode (a set of ;;; singletons). (define (make-asyn vars) (for/set ([v vars]) (set v))) ;;; Given a list of variables, builds the synchronous mode (a set ;;; containing the set of variables). (define (make-syn vars) (set (list->set vars))) ;;; Given a network, applies a function for building a mode to its ;;; variables and returns the corresponding network dynamics. (define (make-dynamics-from-func network mode-func) (dynamics network (mode-func (hash-keys network)))) ;;; Creates the asynchronous dynamics for a given network. (define (make-asyn-dynamics network) (make-dynamics-from-func network make-asyn)) ;;; Creates the synchronous dynamics for a given network. (define (make-syn-dynamics network) (make-dynamics-from-func network make-syn)) ;;; Reads an Org-mode-produced sexp, converts it into a network, and ;;; builds the asyncronous dynamics out of it. (define read-org-network-make-asyn (compose make-asyn-dynamics network-form->network read-org-variable-mapping)) ;;; A shortcut for read-org-network-make-asyn. (define-syntax-rule (unorg-asyn str) (read-org-network-make-asyn str)) ;;; Reads an Org-mode-produced sexp, converts it into a network, and ;;; builds the synchronous dynamics out of it. (define read-org-network-make-syn (compose make-syn-dynamics network-form->network read-org-variable-mapping)) ;;; A shortcut for read-org-network-make-syn. (define-syntax-rule (unorg-syn str) (read-org-network-make-syn str)) ;;; Pretty-prints a state of the network. (define (pretty-print-state s) (string-join (hash-map s (λ (key val) (format "~a:~a" key val)) #t))) ;;; Converts any non-#f value to 1 and #f to 0. (define (any->boolean x) (if x 1 0)) ;;; Pretty-prints a state of the network to Boolean values 0 or 1. (define (pretty-print-boolean-state s) (string-join (hash-map s (λ (key val) (format "~a:~a" key (any->boolean val))) #t))) ;;; Given a state graph and a pretty-printer for states build a new ;;; state graph with pretty-printed vertices and edges. (define (pretty-print-state-graph-with gr pprinter) (update-graph gr #:v-func pprinter #:e-func pretty-print-set-sets)) ;;; Pretty prints a state graph with pretty-print-state. (define (pretty-print-state-graph gr) (pretty-print-state-graph-with gr pretty-print-state)) ;;; A shortcut for pretty-print-state-graph. (define-syntax-rule (ppsg gr) (pretty-print-state-graph gr)) ;;; Pretty prints a state graph with pretty-print-boolean-state. (define (pretty-print-boolean-state-graph gr) (pretty-print-state-graph-with gr pretty-print-boolean-state)) ;;; A shortcut for pretty-print-boolean-state-graph. (define-syntax-rule (ppsgb gr) (pretty-print-boolean-state-graph gr)) ;;; Builds the full state graph of a Boolean network. (define (build-full-boolean-state-graph dyn) (dds-build-state-graph dyn (list->set (build-all-boolean-states (hash-keys (dynamics-network dyn)))))) ;;; Build the full annotated state graph of a Boolean network. (define (build-full-boolean-state-graph-annotated dyn) (dds-build-state-graph-annotated dyn (list->set (build-all-boolean-states (hash-keys (dynamics-network dyn)))))) ;;; ========= ;;; Functions ;;; ========= ;;; Given a function and a list of domains for each of its arguments, ;;; in order, produces a list of lists giving the values of arguments ;;; and the value of the functions for these inputs. (define (tabulate/domain-list func doms) (for/list ([xs (apply cartesian-product doms)]) (append xs (list (apply func xs))))) ;;; Like tabulate, but the domains are given as a rest argument. (define (tabulate func . doms) (tabulate/domain-list func doms)) ;;; Like tabulate, but assumes the domains of all variables of the ;;; function are Boolean. func must have a fixed arity. It is an ;;; error to supply a function of variable arity. (define (tabulate/boolean func) (tabulate/domain-list func (make-list (procedure-arity func) '(#f #t)))) ;;; Given a table like the one produced by the tabulate functions, ;;; creates a function which has this behaviour. ;;; ;;; More exactly, the input is a list of lists of values. All but the ;;; last elements of every list give the values of the parameters of ;;; the function, while the the last element of every list gives the ;;; value of the function. Thus, every list should have at least two ;;; elements. ;;; ;;; The produced function is implemented via lookups in hash tables, ;;; meaning that it may be sometimes more expensive to compute than by ;;; using an direct symbolic implementation. (define (table->function table) (let ([func (table->function/list table)]) (λ args (func args)))) ;;; Like table->function, but the produced function accepts a single ;;; list of arguments instead of individual arguments. (define (table->function/list table) ((curry hash-ref) (for/hash ([line table]) (let-values ([(x fx) (split-at-right line 1)]) (values x (car fx)))))) ;;; Returns the n-th Cartesian power of the Boolean domain: {0,1}^n. (define (boolean-power-n n) (apply cartesian-product (make-list n '(#f #t)))) ;;; Like boolean-power-n, but returns a stream whose elements the ;;; elements of the Cartesian power. (define (boolean-power-n/stream n) (apply cartesian-product/stream (make-list n '(#f #t)))) ;;; Returns the stream of the truth tables of all Boolean functions of ;;; a given arity. ;;; ;;; There are 2^(2^n) Boolean functions of arity n. (define (enumerate-boolean-tables n) (let ([inputs (boolean-power-n n)] [outputs (boolean-power-n (expt 2 n))]) (for/stream ([out outputs]) (for/list ([in inputs] [o out]) (append in (list o)))))) ;;; Returns the stream of all Boolean functions of a given arity. ;;; ;;; There are 2^(2^n) Boolean functions of arity n. (define (enumerate-boolean-functions n) (stream-map table->function (enumerate-boolean-tables n))) ;;; Returns the stream of all Boolean functions of a given arity. As ;;; different from the functions returned by ;;; enumerate-boolean-functions, the functions take lists of arguments ;;; instead of n arguments. ;;; ;;; There are 2^(2^n) Boolean functions of arity n. (define (enumerate-boolean-functions/list n) (stream-map table->function/list (enumerate-boolean-tables n)))