diff --git a/home-manager/home-manager b/home-manager/home-manager
index 390ab47d6..d758653d5 100644
--- a/home-manager/home-manager
+++ b/home-manager/home-manager
@@ -19,7 +19,7 @@ function removeByName() {
 }
 
 function setNixProfileCommands() {
-    if [[ -e ~/.nix-profile/manifest.json ]] ; then
+    if [[ -e $HOME/.nix-profile/manifest.json ]] ; then
         LIST_OUTPATH_CMD="nix profile list"
         REMOVE_CMD="removeByName"
     else
@@ -93,6 +93,23 @@ function setHomeManagerNixPath() {
     done
 }
 
+# Sets some useful Home Manager related paths as global read-only variables.
+function setHomeManagerPathVariables() {
+    declare -r nixStateDir="${NIX_STATE_DIR:-/nix/var/nix}"
+    declare -r globalProfilesDir="$nixStateDir/profiles/per-user/$USER"
+    declare -r globalGcrootsDir="$nixStateDir/gcroots/per-user/$USER"
+
+    declare -gr HM_DATA_HOME="${XDG_DATA_HOME:-$HOME/.local/share}/home-manager"
+    declare -gr HM_STATE_DIR="${XDG_STATE_HOME:-$HOME/.local/state}/home-manager"
+    declare -gr HM_GCROOT_LEGACY_PATH="$globalGcrootsDir/current-home"
+
+    if [[ -d "$globalProfilesDir" ]]; then
+        declare -gr HM_PROFILE_DIR="$globalProfilesDir"
+    else
+        declare -gr HM_PROFILE_DIR="$HM_STATE_DIR/profiles"
+    fi
+}
+
 function setFlakeAttribute() {
     local configFlake="${XDG_CONFIG_HOME:-$HOME/.config}/nixpkgs/flake.nix"
     if [[ -z $FLAKE_ARG && ! -v HOME_MANAGER_CONFIG && -e "$configFlake" ]]; then
@@ -339,7 +356,7 @@ function doListGens() {
         color="always"
     fi
 
-    pushd "$NIX_STATE_DIR/profiles/per-user/$USER" > /dev/null
+    pushd "$HM_PROFILE_DIR" > /dev/null
     # shellcheck disable=2012
     ls --color=$color -gG --time-style=long-iso --sort time home-manager-*-link \
         | cut -d' ' -f 4- \
@@ -352,7 +369,7 @@ function doListGens() {
 function doRmGenerations() {
     setVerboseAndDryRun
 
-    pushd "$NIX_STATE_DIR/profiles/per-user/$USER" > /dev/null
+    pushd "$HM_PROFILE_DIR" > /dev/null
 
     for generationId in "$@"; do
         local linkName="home-manager-$generationId-link"
@@ -370,17 +387,10 @@ function doRmGenerations() {
     popd > /dev/null
 }
 
-function doRmAllGenerations() {
-    $DRY_RUN_CMD rm $VERBOSE_ARG \
-        "$NIX_STATE_DIR/profiles/per-user/$USER/home-manager"*
-}
-
 function doExpireGenerations() {
-    local profileDir="$NIX_STATE_DIR/profiles/per-user/$USER"
-
     local generations
     generations="$( \
-        find "$profileDir" -name 'home-manager-*-link' -not -newermt "$1" \
+        find "$HM_PROFILE_DIR" -name 'home-manager-*-link' -not -newermt "$1" \
         | sed 's/^.*-\([0-9]*\)-link$/\1/' \
     )"
 
@@ -482,6 +492,7 @@ function doUninstall() {
     read -r -n 1 -p "$(_i 'Really uninstall Home Manager?') [y/n] " confirmation
     echo
 
+    # shellcheck disable=2086
     case $confirmation in
         y|Y)
             _i "Switching to empty Home Manager configuration..."
@@ -493,10 +504,22 @@ function doUninstall() {
             doSwitch
             $DRY_RUN_CMD $REMOVE_CMD home-manager-path || true
             rm "$HOME_MANAGER_CONFIG"
-            $DRY_RUN_CMD rm $VERBOSE_ARG -r \
-                "${XDG_DATA_HOME:-$HOME/.local/share}/home-manager"
-            $DRY_RUN_CMD rm $VERBOSE_ARG \
-                "$NIX_STATE_DIR/gcroots/per-user/$USER/current-home"
+
+            if [[ -e $HM_DATA_HOME ]]; then
+                $DRY_RUN_CMD rm $VERBOSE_ARG -r "$HM_DATA_HOME"
+            fi
+
+            if [[ -e $HM_PROFILE_DIR ]]; then
+                $DRY_RUN_CMD rm $VERBOSE_ARG "$HM_PROFILE_DIR/home-manager"*
+            fi
+
+            if [[ -e $HM_GCROOT_LEGACY_PATH ]]; then
+                $DRY_RUN_CMD rm $VERBOSE_ARG "$HM_GCROOT_LEGACY_PATH"
+            fi
+
+            if [[ -e $HM_STATE_DIR ]]; then
+                $DRY_RUN_CMD rm $VERBOSE_ARG -r "$HM_STATE_DIR"
+            fi
             ;;
         *)
             _i "Yay!"
@@ -504,22 +527,6 @@ function doUninstall() {
             ;;
     esac
 
-    local deleteProfiles
-    read -r -n 1 \
-         -p "$(_i 'Remove all Home Manager generations?') [y/n] " \
-         deleteProfiles
-    echo
-
-    case $deleteProfiles in
-        y|Y)
-            doRmAllGenerations
-            _i 'All generations are now eligible for garbage collection.'
-            ;;
-        *)
-            _i 'Leaving generations but they may still be garbage collected.'
-            ;;
-    esac
-
     _i "Home Manager is uninstalled but your home.nix is left untouched."
 }
 
@@ -591,8 +598,6 @@ function doHelp() {
     echo "  uninstall    Remove Home Manager"
 }
 
-readonly NIX_STATE_DIR="${NIX_STATE_DIR:-/nix/var/nix}"
-
 EXTRA_NIX_PATH=()
 HOME_MANAGER_CONFIG_ATTRIBUTE=""
 PASSTHROUGH_OPTS=()
@@ -601,6 +606,7 @@ COMMAND_ARGS=()
 FLAKE_ARG=""
 
 setHomeManagerNixPath
+setHomeManagerPathVariables
 
 while [[ $# -gt 0 ]]; do
     opt="$1"
diff --git a/home-manager/po/home-manager.pot b/home-manager/po/home-manager.pot
index 003a344b0..a6a77c7f3 100644
--- a/home-manager/po/home-manager.pot
+++ b/home-manager/po/home-manager.pot
@@ -8,7 +8,7 @@ msgid ""
 msgstr ""
 "Project-Id-Version: Home Manager\n"
 "Report-Msgid-Bugs-To: https://github.com/nix-community/home-manager/issues\n"
-"POT-Creation-Date: 2022-03-26 15:08+0100\n"
+"POT-Creation-Date: 2023-03-07 23:36+0100\n"
 "PO-Revision-Date: YEAR-MO-DA HO:MI+ZONE\n"
 "Last-Translator: FULL NAME <EMAIL@ADDRESS>\n"
 "Language-Team: LANGUAGE <LL@li.org>\n"
@@ -26,15 +26,15 @@ msgstr ""
 msgid "No configuration file found. Please create one at %s"
 msgstr ""
 
-#: home-manager/home-manager:122
+#: home-manager/home-manager:146
 msgid "Can't inspect options of a flake configuration"
 msgstr ""
 
-#: home-manager/home-manager:162
+#: home-manager/home-manager:185
 msgid "Can't instantiate a flake configuration"
 msgstr ""
 
-#: home-manager/home-manager:237
+#: home-manager/home-manager:258
 msgid ""
 "There is %d unread and relevant news item.\n"
 "Read it by running the command \"%s news\"."
@@ -44,92 +44,80 @@ msgid_plural ""
 msgstr[0] ""
 msgstr[1] ""
 
-#: home-manager/home-manager:251
+#: home-manager/home-manager:272
 msgid "Unknown \"news.display\" setting \"%s\"."
 msgstr ""
 
-#: home-manager/home-manager:258
+#: home-manager/home-manager:279
 #, sh-format
 msgid "Please set the $EDITOR environment variable"
 msgstr ""
 
-#: home-manager/home-manager:273
+#: home-manager/home-manager:294
 msgid "Cannot run build in read-only directory"
 msgstr ""
 
-#: home-manager/home-manager:355
+#: home-manager/home-manager:378
 msgid "No generation with ID %s"
 msgstr ""
 
-#: home-manager/home-manager:357
+#: home-manager/home-manager:380
 msgid "Cannot remove the current generation %s"
 msgstr ""
 
-#: home-manager/home-manager:359
+#: home-manager/home-manager:382
 msgid "Removing generation %s"
 msgstr ""
 
-#: home-manager/home-manager:385
+#: home-manager/home-manager:401
 msgid "No generations to expire"
 msgstr ""
 
-#: home-manager/home-manager:396
+#: home-manager/home-manager:412
 msgid "No home-manager packages seem to be installed."
 msgstr ""
 
-#: home-manager/home-manager:453
+#: home-manager/home-manager:469
 msgid "Unknown argument %s"
 msgstr ""
 
-#: home-manager/home-manager:469
+#: home-manager/home-manager:485
 msgid "This will remove Home Manager from your system."
 msgstr ""
 
-#: home-manager/home-manager:472
+#: home-manager/home-manager:488
 msgid "This is a dry run, nothing will actually be uninstalled."
 msgstr ""
 
-#: home-manager/home-manager:476
+#: home-manager/home-manager:492
 msgid "Really uninstall Home Manager?"
 msgstr ""
 
-#: home-manager/home-manager:481
+#: home-manager/home-manager:498
 msgid "Switching to empty Home Manager configuration..."
 msgstr ""
 
-#: home-manager/home-manager:493
+#: home-manager/home-manager:525
 msgid "Yay!"
 msgstr ""
 
-#: home-manager/home-manager:500
-msgid "Remove all Home Manager generations?"
-msgstr ""
-
-#: home-manager/home-manager:507
-msgid "All generations are now eligible for garbage collection."
-msgstr ""
-
-#: home-manager/home-manager:510
-msgid "Leaving generations but they may still be garbage collected."
-msgstr ""
-
-#: home-manager/home-manager:514
+#: home-manager/home-manager:530
 msgid "Home Manager is uninstalled but your home.nix is left untouched."
 msgstr ""
 
-#: home-manager/home-manager:673
+#: home-manager/home-manager:695
 msgid "%s: unknown option '%s'"
 msgstr ""
 
-#: home-manager/home-manager:674
+#: home-manager/home-manager:696
 msgid "Run '%s --help' for usage help"
 msgstr ""
 
-#: home-manager/home-manager:708
+#: home-manager/home-manager:730
 msgid "expire-generations expects one argument, got %d."
 msgstr ""
 
-#: home-manager/home-manager:730
+#: home-manager/home-manager:752
 msgid "Unknown command: %s"
 msgstr ""
 
diff --git a/modules/files.nix b/modules/files.nix
index 0f4207fe8..4f64a9f86 100644
--- a/modules/files.nix
+++ b/modules/files.nix
@@ -272,7 +272,10 @@ in
               $DRY_RUN_CMD nix-env $VERBOSE_ARG --profile "$genProfilePath" --set "$newGenPath"
             fi
 
-            $DRY_RUN_CMD ln -Tsf $VERBOSE_ARG "$newGenPath" "$newGenGcPath"
+            $DRY_RUN_CMD nix-store --realise "$newGenPath" --add-root "$newGenGcPath" > "$DRY_RUN_NULL"
+            if [[ -e "$legacyGenGcPath" ]]; then
+              $DRY_RUN_CMD rm $VERBOSE_ARG "$legacyGenGcPath"
+            fi
           else
             _i "No change so reusing latest profile generation %s" "$oldGenNum"
           fi
diff --git a/modules/home-environment.nix b/modules/home-environment.nix
index 098e10b21..aca3723ef 100644
--- a/modules/home-environment.nix
+++ b/modules/home-environment.nix
@@ -584,7 +584,7 @@ in
       if config.submoduleSupport.externalPackageInstall
       then
         ''
-          if [[ -e "$nixProfilePath"/manifest.json ]] ; then
+          if [[ -e $HOME/.nix-profile/manifest.json ]] ; then
             nix profile list \
               | { grep 'home-manager-path$' || test $? = 1; } \
               | cut -d ' ' -f 4 \
@@ -608,7 +608,7 @@ in
             $DRY_RUN_CMD $oldNix profile install $1
           }
 
-          if [[ -e "$nixProfilePath"/manifest.json ]] ; then
+          if [[ -e $HOME/.nix-profile/manifest.json ]] ; then
             INSTALL_CMD="nix profile install"
             INSTALL_CMD_ACTUAL="nixReplaceProfile"
             LIST_CMD="nix profile list"
diff --git a/modules/lib-bash/activation-init.sh b/modules/lib-bash/activation-init.sh
index 3b0f5320a..e719352dc 100644
--- a/modules/lib-bash/activation-init.sh
+++ b/modules/lib-bash/activation-init.sh
@@ -1,14 +1,60 @@
+# Moves the existing profile from /nix to ~ to match changed behavior in Nix
+# 2.14. See https://github.com/NixOS/nix/pull/5226.
+#
+# Note, this function is intentionally unused for now. There remains a few open
+# questions about backwards compatibility and support from
+# `nix-collect-garbage`.
+function migrateProfile() {
+    declare -r stateHome="${XDG_STATE_HOME:-$HOME/.local/state}"
+    declare -r hmStateDir="$stateHome/home-manager"
+    declare -r nixStateDir="${NIX_STATE_DIR:-/nix/var/nix}"
+
+    declare -r newProfilesDir="$hmStateDir/profiles"
+    declare -r oldProfilesDir="$nixStateDir/profiles/per-user/$USER"
+
+    if [[ ! -d $newProfilesDir ]]; then
+        _i 'Migrating profiles from %s to %s' "$oldProfilesDir" "$newProfilesDir"
+        mkdir -p "$newProfilesDir"
+        for p in "$oldProfilesDir"/home-manager-*; do
+            declare -r name="${p##*/}"
+            nix-store --realise "$p" --add-root "$newProfilesDir/$name" > /dev/null
+        done
+        cp -P "$oldProfilesDir/home-manager" "$newProfilesDir"
+    fi
+
+    rm "$oldProfilesDir"/home-manager-*
+}
+
 function setupVars() {
-    local nixStateDir="${NIX_STATE_DIR:-/nix/var/nix}"
-    local profilesPath="$nixStateDir/profiles/per-user/$USER"
-    local gcPath="$nixStateDir/gcroots/per-user/$USER"
+    declare -r nixStateDir="${NIX_STATE_DIR:-/nix/var/nix}"
+    declare -r globalProfilesDir="$nixStateDir/profiles/per-user/$USER"
+    declare -r globalGcrootsDir="$nixStateDir/gcroots/per-user/$USER"
 
-    declare -gr nixProfilePath="$profilesPath/profile"
-    declare -gr genProfilePath="$profilesPath/home-manager"
+    declare -r stateHome="${XDG_STATE_HOME:-$HOME/.local/state}"
+    declare -r hmStateDir="$stateHome/home-manager"
+    declare -r hmGcrootsDir="$hmStateDir/gcroots"
+
+    # If the global profiles path exists or we can create it, then place the HM
+    # profile there. Otherwise place it in the HM data directory. We prefer to
+    # use the global location since it makes it visible to
+    # `nix-collect-garbage`.
+    #
+    # In the future we may perform a one-shot migration to the new location.
+    #
+    # shellcheck disable=2174
+    if [[ -d "$globalProfilesDir" ]] || mkdir -m 0755 -p "$globalProfilesDir"; then
+        declare -r hmProfilesDir="$globalProfilesDir"
+    else
+        declare -r hmProfilesDir="$hmStateDir/profiles"
+        mkdir -m 0755 -p "$hmProfilesDir"
+    fi
+
+    declare -gr genProfilePath="$hmProfilesDir/home-manager"
     declare -gr newGenPath="@GENERATION_DIR@";
-    declare -gr newGenGcPath="$gcPath/current-home"
+    declare -gr newGenGcPath="$hmGcrootsDir/current-home"
+    declare -gr legacyGenGcPath="$globalGcrootsDir/current-home"
 
-    local greatestGenNum
+    declare greatestGenNum
     greatestGenNum=$( \
         nix-env --list-generations --profile "$genProfilePath" \
             | tail -1 \
@@ -21,9 +67,9 @@ function setupVars() {
         declare -gr newGenNum=1
     fi
 
-    if [[ -e $profilesPath/home-manager ]] ; then
-        oldGenPath="$(readlink -e "$profilesPath/home-manager")"
-        declare -gr oldGenPath
+    if [[ -e $genProfilePath ]] ; then
+        declare -g oldGenPath
+        oldGenPath="$(readlink -e "$genProfilePath")"
     fi
 
     $VERBOSE_RUN _i "Sanity checking oldGenNum and oldGenPath"
@@ -31,7 +77,7 @@ function setupVars() {
             || ! -v oldGenNum && -v oldGenPath ]]; then
         _i $'The previous generation number and path are in conflict! These\nmust be either both empty or both set but are now set to\n\n    \'%s\' and \'%s\'\n\nIf you don\'t mind losing previous profile generations then\nthe easiest solution is probably to run\n\n   rm %s/home-manager*\n   rm %s/current-home\n\nand trying home-manager switch again. Good luck!' \
            "${oldGenNum:-}" "${oldGenPath:-}" \
-           "$profilesPath" "$gcPath"
+           "$hmProfilesDir" "$hmGcrootsDir"
         exit 1
     fi
 }
@@ -58,9 +104,12 @@ setupVars
 if [[ -v DRY_RUN ]] ; then
     _i "This is a dry run"
     export DRY_RUN_CMD=echo
+    export DRY_RUN_NULL=/dev/stdout
 else
     $VERBOSE_RUN _i "This is a live run"
     export DRY_RUN_CMD=""
+    export DRY_RUN_NULL=/dev/null
+
 fi
 
 if [[ -v VERBOSE ]]; then
@@ -77,5 +126,6 @@ else
 fi
 $VERBOSE_ECHO "  newGenPath=$newGenPath"
 $VERBOSE_ECHO "  newGenNum=$newGenNum"
-$VERBOSE_ECHO "  newGenGcPath=$newGenGcPath"
 $VERBOSE_ECHO "  genProfilePath=$genProfilePath"
+$VERBOSE_ECHO "  newGenGcPath=$newGenGcPath"
+$VERBOSE_ECHO "  legacyGenGcPath=$legacyGenGcPath"
diff --git a/modules/po/hm-modules.pot b/modules/po/hm-modules.pot
index 7bff64af4..8bbcc221b 100644
--- a/modules/po/hm-modules.pot
+++ b/modules/po/hm-modules.pot
@@ -8,7 +8,7 @@ msgid ""
 msgstr ""
 "Project-Id-Version: Home Manager Modules\n"
 "Report-Msgid-Bugs-To: https://github.com/nix-community/home-manager/issues\n"
-"POT-Creation-Date: 2022-03-26 15:08+0100\n"
+"POT-Creation-Date: 2023-03-07 23:36+0100\n"
 "PO-Revision-Date: YEAR-MO-DA HO:MI+ZONE\n"
 "Last-Translator: FULL NAME <EMAIL@ADDRESS>\n"
 "Language-Team: LANGUAGE <LL@li.org>\n"
@@ -17,23 +17,23 @@ msgstr ""
 "Content-Type: text/plain; charset=CHARSET\n"
 "Content-Transfer-Encoding: 8bit\n"
 
-#: modules/files.nix:233
+#: modules/files.nix:234
 msgid "Creating home file links in %s"
 msgstr ""
 
-#: modules/files.nix:246
+#: modules/files.nix:247
 msgid "Cleaning up orphan links from %s"
 msgstr ""
 
-#: modules/files.nix:262
+#: modules/files.nix:263
 msgid "Creating profile generation %s"
 msgstr ""
 
-#: modules/files.nix:276
+#: modules/files.nix:280
 msgid "No change so reusing latest profile generation %s"
 msgstr ""
 
-#: modules/home-environment.nix:607
+#: modules/home-environment.nix:625
 msgid ""
 "Oops, Nix failed to install your new Home Manager profile!\n"
 "\n"
@@ -49,15 +49,19 @@ msgid ""
 "Then try activating your Home Manager configuration again."
 msgstr ""
 
-#: modules/home-environment.nix:639
+#: modules/home-environment.nix:658
 msgid "Activating %s"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:31
+#: modules/lib-bash/activation-init.sh:18
+msgid "Migrating profiles from %s to %s"
+msgstr ""
+
+#: modules/lib-bash/activation-init.sh:77
 msgid "Sanity checking oldGenNum and oldGenPath"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:34
+#: modules/lib-bash/activation-init.sh:80
 msgid ""
 "The previous generation number and path are in conflict! These\n"
 "must be either both empty or both set but are now set to\n"
@@ -73,26 +77,26 @@ msgid ""
 "and trying home-manager switch again. Good luck!"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:51
+#: modules/lib-bash/activation-init.sh:97
 msgid "Starting Home Manager activation"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:55
+#: modules/lib-bash/activation-init.sh:101
 msgid "Sanity checking Nix"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:61
+#: modules/lib-bash/activation-init.sh:107
 msgid "This is a dry run"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:64
+#: modules/lib-bash/activation-init.sh:111
 msgid "This is a live run"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:69
+#: modules/lib-bash/activation-init.sh:118
 msgid "Using Nix version: %s"
 msgstr ""
 
-#: modules/lib-bash/activation-init.sh:72
+#: modules/lib-bash/activation-init.sh:121
 msgid "Activation variables:"
 msgstr ""